6-Fluoro-1H-indole-3-carboxylic acid
نویسندگان
چکیده
In the title compound, C(9)H(6)FNO(2), all the non-H atoms are approximately coplanar, the carb-oxy O atoms deviating by 0.0809 and -0.1279 Å from the indole plane. In the crystal, O-H⋯O hydrogen bonds link the mol-ecules into dimers which are linked via N-H⋯O hydrogen bonds and π-π inter-actions [centroid-centroid distance = 3.680 (2) Å].
منابع مشابه
5-Fluoro-1H-indole-3-carboxylic acid
In the title compound, C(9)H(6)FNO(2), the carboxyl group is twisted slightly away from the indole-ring plane [dihedral angle = 7.39 (10)°]. In the crystal, carboxyl inversion dimers linked by pairs of O-H⋯O hydrogen bonds generate R(2) (2)(8) loops and N-H⋯O hydrogen bonds connect the dimers into (10[Formula: see text]) sheets.
متن کامل5-Chloro-1H-indole-3-carboxylic acid
In the title compound, C(9)H(6)ClNO(2), the carboxyl group is twisted from the indole ring system by 9.00 (8)°. In the crystal, inversion dimers linked by pairs of O-H⋯O hydrogen bonds generate R(2) (2)(8) loops and N-H⋯O hydrogen bonds link the dimers into (001) sheets. Aromatic π-π stacking inter-actions [centroid-centroid distance = 3.7185 (12) A °] are also observed.
متن کامل3-Carboxymethyl-1H-indole-4-carboxylic acid
In the title compound, C(11)H(9)NO(4), the carboxyl group bonded to the six-membered ring lies close to the plane of the 1H-indole ring system [dihedral angle = 13.13 (9)°], whereas the carb-oxy-lic acid group linked to the five-membered ring by a methyl-ene bridge is close to perpendicular [78.85 (9)°]. In the crystal, O-H⋯O and N-H⋯O hydrogen bonds link the mol-ecules, generating (110) sheets.
متن کامل6-Bromo-1H-indole-3-carboxylic acid
In the title mol-ecule, C(9)H(6)BrNO(2), the dihedral angle between the -COOH group and the ring system is 6 (4)°. In the crystal, pairs of O-H⋯O hydrogen bonds link the mol-ecules into inversion dimers and these dimers are connected via N-H⋯O hydrogen bonds to form layers parallel to the (-101) plane.
متن کاملSynthesis and anti-hyperlipidemic evaluation of N‑(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats.
The lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (1), C2: N-(3-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (2), C...
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